کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2505860 1557502 2007 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Liposomal amphotericin B eye drops to treat fungal keratitis: Physico-chemical and formulation stability
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی علوم دارویی
پیش نمایش صفحه اول مقاله
Liposomal amphotericin B eye drops to treat fungal keratitis: Physico-chemical and formulation stability
چکیده انگلیسی

Local fungal infections with Candida, Fusarium, Curvularia and Aspergillus can lead to serious ulceration of the cornea and must be treated rapidly. The current treatment consists of 0.15% (w/v) amphotericin B eye drops prepared from Fungizone®, containing deoxycholate, irritant for the cornea, which reduces patient compliance. Eye drops based on liposomal amphotericin B (AmBisome®) would be a convenient alternative; however, according to the manufacturer's instructions, AmBisome® can only be kept refrigerated for 1 week after reconstitution. A longer shelf-life at ambient temperature would be preferable for a preparation made in a hospital pharmacy and delivered to patients. Thus, the possibility of storing an ophthalmic preparation of 0.5% (w/v) liposomal amphotericin B after reconstitution was investigated. After 6 months at room temperature or at +2–8 °C, the hydrodynamic diameter measured by quasi-elastic light scattering remained constant at 108 ± 30 nm with a polydispersity index lower than 0.15. Amphotericin B content, checked by a validated HPLC method, was maintained between 94 and 107%. Amphotericin B and soy phosphatidylcholine proportions remained constant, indicating that the liposomes remained intact and retained the drug. These results show the feasibility of an ophthalmic preparation based on liposomal amphotericin B developed in hospital pharmacies.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Pharmaceutics - Volume 344, Issues 1–2, 1 November 2007, Pages 150–153
نویسندگان
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