کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2505912 | 1557499 | 2008 | 6 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Preparation of an extended-release matrix tablet using chitosan/Carbopol interpolymer complex Preparation of an extended-release matrix tablet using chitosan/Carbopol interpolymer complex](/preview/png/2505912.png)
A chitosan and Carbopol interpolymer complex (IPC) was formed using a precipitation method in an acidic solution. The chitosan and Carbopol IPC was characterized by Fourier transform infrared spectroscopy (FT-IR), differential scanning calorimetry (DSC), and turbidity measurements. FT-IR demonstrated that the IPC formed a complex through an electrostatic interaction between the protonated amine (NH3+) group of chitosan and the carboxylate (COO−) group of Carbopol. DSC indicated the IPC to have different thermal characteristics from chitosan or Carbopol. The turbidity measurement revealed the complexation ratio of IPC between chitosan/Carbopol to be 1/4. A theophylline tablet was prepared using the IPC as a matrix material. The drug release profile from this tablet was similar to that from the HPMC tablet and showed a pH-independent release profile. The mechanisms for drug release from the IPC tablet were diffusional release at pH 6.8 and relaxational release at pH 1.2.
Journal: International Journal of Pharmaceutics - Volume 347, Issues 1–2, 22 January 2008, Pages 39–44