کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2505926 | 1557499 | 2008 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Oral delivery of insulin loaded poly(fumaric-co-sebacic) anhydride microspheres
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
علوم دارویی
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چکیده انگلیسی
The bioadhesive polymer, poly(fumaric-co-sebacic) anhydride, p(FASA), was used to fabricate small diameter insulin microspheres and evaluate their in vivo performance in a type 1 diabetic rat as well as a type 1 diabetic dog model. The process of phase inversion nanoencapsulation was used to fabricate p(FASA) microspheres containing insulin. Using laser diffraction spectrometry, 90% of the microspheres used in the fed double dose rat experiments were found to have a volumetric diameter of 5.9 μm or smaller. In comparison, 90% of the microspheres used in fed single dose rat experiments were found to have a volumetric diameter of 2.6 μm or smaller while the microspheres used in the diabetic dog experiments were found to have a volumetric diameter of 1.2 μm or smaller. Insulin microspheres administered to diabetic rats in the fed double dose experiment produced a relative bioavailability (RB) of 23.3% while insulin microspheres administered to diabetic rats in the fed single dose experiment produced a RB of 5.5 ± 1.7%. Insulin microspheres administered to fasted diabetic dogs produced a RB of 5.5 ± 3.4%.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Pharmaceutics - Volume 347, Issues 1â2, 22 January 2008, Pages 149-155
Journal: International Journal of Pharmaceutics - Volume 347, Issues 1â2, 22 January 2008, Pages 149-155
نویسندگان
Stacia Furtado, Danielle Abramson, Roxanne Burrill, Gloria Olivier, Celinda Gourd, Emily Bubbers, Edith Mathiowitz,