کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2505935 1557504 2007 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Solubilization of poorly soluble compounds using 2-pyrrolidone
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی علوم دارویی
پیش نمایش صفحه اول مقاله
Solubilization of poorly soluble compounds using 2-pyrrolidone
چکیده انگلیسی

The solubilization of nine poorly soluble compounds in aqueous solution by 2-pyrrolidone has been studied. Solubility enhancement as high as 500-fold is achieved using 20% 2-pyrrolidone. A comparison shows that 2-pyrrolidone is a better solubilizer than glycerin, propylene glycol, polyethylene glycol 400 or ethanol. The observed solubilization curves are deconvoluted into components representing complexation and cosolvency. A clear linear relationship exists between the cosolvency solubilization power (σ) of 2-pyrrolidone and the partition coefficient (log Kow) of the drug (R2 = 0.96) extending over three orders of magnitude. The stability constants for the formation of 1:1 complex (K1:1) involving 2-pyrrolidone and the drugs have been calculated. A weaker correlation (R2 = 0.74) is observed between the complexation constants and the partition coefficients of respective drugs. This study indicates that 2-pyrrolidone, like NMP, can act as a complexant at low concentrations and as a cosolvent at high concentrations and that both these properties are affected by the partition coefficient of the solute.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Pharmaceutics - Volume 342, Issues 1–2, 5 September 2007, Pages 1–5
نویسندگان
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