کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2505937 | 1557504 | 2007 | 8 صفحه PDF | دانلود رایگان |

Texture analysis is a new approach in pharmaceutical research and development; this study evaluated the correlation between drug dissolution and polymer hydration from a modified release matrix tablet of pseudoephedrine hydrochloride using a texture analyzer. A series of matrix tablets of pseudoephedrine was designed and prepared. Modified drug release was achieved by combined use of matrix excipients Polyox® WSR301 (PEO) and Compritol® 888ATO (GB). Dissolution profiles of the tablets were assessed using USP Method II. Polymer swelling behaviors during dissolution were measured using a texture analyzer. Increase in proportion of PEO and GB in the formulation reduced drug dissolution within the first 90 min. However, drug release was complete in 6 h due to high aqueous solubility of pseudoephedrine. Linear correlations were observed among drug dissolution, polymer content and parameters of texture analysis including hydrogel thickness and AUCTA for formulations that contained hydrophilic PEO. The study demonstrated a unique application of a texture analyzer in characterization of modified release matrix tablets.
Journal: International Journal of Pharmaceutics - Volume 342, Issues 1–2, 5 September 2007, Pages 18–25