کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2506029 1557503 2007 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Preparation and characteristic of vinorelbine bitartrate-loaded solid lipid nanoparticles
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی علوم دارویی
پیش نمایش صفحه اول مقاله
Preparation and characteristic of vinorelbine bitartrate-loaded solid lipid nanoparticles
چکیده انگلیسی

A hydrophilic and temperature-induced degradation drug, vinorelbine bitartrate (VB)-loaded solid lipid nanoparticles (SLNs) were prepared by a cold homogenization technique. The physicochemical properties of the SLNs, with various lipid composition, drug content and altered homogenizing times, were investigated. The mean particle size of the SLNs ranged from 150 to 350 nm. The enhancement of lecithin content in lipid matrix resulted in smaller particle of SLNs. The atomic force microscopy (AFM) images displayed that the shape of the SLNs was irregular sphere with smooth surface. The drug entrapment efficiency (EE) could be improved with the increasing of lecithin or oleic acid content in lipid matrix, and reduced with the added amount of drug. The highest EE and drug loading capacity (DL) could reach up to 80 and 6.6%, respectively. The studies of drug release showed that the drug release could last for 48 h, and the rate was delayed by the addition of lecithin or oleic acid in the formulations. The physical stability experiment indicated that the SLNs were stable for 2 months under room temperature. Moreover, the cellular cytotoxicity of VB against MCF-7 cells could be improved by the entrapment of SLNs.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Pharmaceutics - Volume 343, Issues 1–2, 1 October 2007, Pages 270–276
نویسندگان
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