Prostaglandin E2 and interleukin-8 production in human epidermal keratinocytes exposed to marine lipid-based liposomes

In response to exogenous stimuli such as non-sensitizing contact irritants, human keratinocytes produce various types of soluble pro-inflammatory mediators including prostaglandin E2 (PGE2) and interleukin 8 (IL-8). Polyunsaturated fatty acids of the n − 3 series (n − 3 PUFA) are known to play a role in the prevention of the inflammatory response. In this work, n − 3 PUFA were supplied to keratinocytes through Marinosomes® that are liposomes based on a natural marine lipid extract. Marinosomes® contributed to reduce inflammation induced by croton oil by regulating PGE2 and IL-8 production in human keratinocyte cultures. However, the preventing effect of Marinosomes® was highly dependent on the lipid concentration used and the liposome mean diameter.