کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2506122 1557510 2007 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
In vitro evaluation of quercetin-3-O-acyl esters as topical prodrugs
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی علوم دارویی
پیش نمایش صفحه اول مقاله
In vitro evaluation of quercetin-3-O-acyl esters as topical prodrugs
چکیده انگلیسی

Quercetin-3-O-acyl esters (I–VI) were synthesized and their usefulness as quercetin topical prodrugs was evaluated. Quercetin esters were assayed to determine their water stability and solubility, their susceptibility to undergoing enzymatic hydrolysis and their permeation through excised human skin. Quercetin ethyl (I) and hexyl (IV) esters proved poorly stable in aqueous media and they were not assayed further. Among the derivatives tested, quercetin propyl (II) and butyl (III) esters were more water-soluble than the parent drug. Esters II, III and V were readily hydrolyzed by human plasma and esters II and III penetrated excised human skin better than quercetin from aqueous saturated solutions. On the basis of the results obtained, esters II and III could be regarded as promising quercetin topical prodrugs.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Pharmaceutics - Volume 336, Issue 2, 24 May 2007, Pages 257–262
نویسندگان
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