کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2506328 1557515 2007 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Dose-independent pharmacokinetics of clindamycin after intravenous and oral administration to rats: Contribution of gastric first-pass effect to low bioavailability
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی علوم دارویی
پیش نمایش صفحه اول مقاله
Dose-independent pharmacokinetics of clindamycin after intravenous and oral administration to rats: Contribution of gastric first-pass effect to low bioavailability
چکیده انگلیسی

The pharmacokinetic parameters of clindamycin were evaluated after intravenous (at doses of 50, 100, and 200 mg/kg) and oral (at doses of 75, 150, and 300 mg/kg) administration of the drug to rats. The first-pass effect of clindamycin was also evaluated after intraportal, intragastric, and intraduodenal administration of the drug at a dose of 150 mg/kg to rats. After both intravenous and oral administration of clindamycin, the pharmacokinetic parameters of the drug were dose-independent. Hence, the extent of absolute oral bioavailability (F) was also independent of oral doses. After oral administration of clindamycin (150 mg/kg), 7.68% of oral dose was not absorbed up to 24 h and F value was 28.2%. The gastric first-pass effect of clindamycin was 60.7% of oral dose. The first-pass effects of clindamycin in the lung, heart, intestine, and liver were almost negligible, if any, in rats. The low F of clindamycin in rats was mainly due to considerable gastric first-pass effect. Clindamycin was stable in rat gastric juice and various buffer solutions having pHs ranging from 1 to 13. The plasma-to-blood cells partition ratio of clindmaycin was 7.59 in rat blood. The plasma protein binding of clindamycin in rats was 67.5%.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Pharmaceutics - Volume 332, Issues 1–2, 6 March 2007, Pages 17–23
نویسندگان
, ,