کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2506330 1557515 2007 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Influence of ethanol on aspirin release from hypromellose matrices
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی علوم دارویی
پیش نمایش صفحه اول مقاله
Influence of ethanol on aspirin release from hypromellose matrices
چکیده انگلیسی

Release profiles of aspirin from hypromellose matrices in hydro-ethanolic media were studied. Percent aspirin released increased with increasing levels of ethanol in the dissolution media, correlating with the drug's solubility, however, dose dumping of aspirin did not occur. An initial rapid release was observed in media comprising 40% ethanol. Release in these conditions was considered to be both erosion and diffusion-mediated, in contrast to the release in 0, 10, 20 and 30% ethanol media, where erosion-controlled release dominated. Image analysis of matrix swelling indicated a slower initial interaction between ethanol and hypromellose accounting for the initial rapid release. Cloud point studies suggested that ethanol retarded hydration of the polymer.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Pharmaceutics - Volume 332, Issues 1–2, 6 March 2007, Pages 31–37
نویسندگان
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