کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2506407 1557513 2007 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Improved bioavailability of orally administered mifepristone from PLGA nanoparticles
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی علوم دارویی
پیش نمایش صفحه اول مقاله
Improved bioavailability of orally administered mifepristone from PLGA nanoparticles
چکیده انگلیسی

The objective of this study was to prepare an oral dosage formulation of mifepristone that will improve the oral bioavailability of mifepristone and sustain the release of mifepristone for at least 3 days to effectively control reproduction, especially in coyotes. Nanoparticles containing mifepristone were prepared from dl-lactide/glycolide copolymers (PLGA). Encapsulation efficiency of the nanoparticles was determined by HPLC. In vitro release study was done in 30% isopropyl alcohol in water. In vivo bioavailability study was performed in male rats. Mifepristone and drug-loaded 50/50 PLGA, MW 4.4 kDa, nanoparticles (equivalent to 100 mg/kg mifepristone) were administered orally to rats. The concentration of mifepristone in serum at different time intervals was determined by HPLC. The average sizes of 50/50 PLGA (MW 4.4 and 13 kDa) nanoparticles containing mifepristone were 516 and 468 nm, respectively. The drug encapsulation efficiency was 75.6% at 20% drug loading in 50/50 PLGA (MW 4.4 kDa) nanoparticles. In vitro cumulative release of mifepristone from the 50/50 PLGA (MW 4.4 and 13 kDa) nanoparticles with 20% drug loading was 60% and 48% in 72 h, respectively. In vivo studies in rats demonstrated that PLGA-1A-nanoparticles increase the bioavailability of mifepristone. We are currently using the nanoparticles containing mifepristone for efficacy studies in coyotes.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Pharmaceutics - Volume 334, Issues 1–2, 4 April 2007, Pages 173–178
نویسندگان
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