کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2506517 | 1557519 | 2007 | 12 صفحه PDF | دانلود رایگان |
The Flynn database (n = 97) for determining the effect of the physicochemical properties of solutes on their skin absorption has been edited to give a database for which the solubilities of the solutes in water, SAQ, and their maximum fluxes from water through human skin in vitro, JMAQ, are known or can be calculated (n = 76). Data from the six major contributors to the original Flynn database have been included. Data for solutes, which were significantly ionized or for experiments using different thicknesses of skin were not excluded so that the edited database is as diverse as the original. The edited database was fit to five equations where the independent variables were solubility in octanol (SOCT) in water (SAQ) or molecular weight (MW), and combinations of those three variables; and the dependent variable was JMAQ. The best fit was obtained from the Roberts–Sloan (RS) equation: log JMAQ = x + y log SOCT + (1 − y) log SAQ − z MW, x = −3.00, y = 0.73, z = 0.0048, r2 = 0.934, S.D. = 0.37 and F = 274. This result is important because J (amount/area time) is the more clinically useful descriptor of permeation compared to P (distance/time); and because the identification of SAQ as a significant variable in predicting flux changes the design parameters for optimizing topical delivery of drugs from solubility in lipids (or partition coefficients between OCT and AQ, KOCT:AQ) and MW, to solubility in lipids, SOCT, and in water, SAQ, as well as MW.
Journal: International Journal of Pharmaceutics - Volume 329, Issues 1–2, 1 February 2007, Pages 25–36