کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2506536 1557519 2007 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Novel poloxamer-based nanoemulsions to enhance the intestinal absorption of active compounds
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی علوم دارویی
پیش نمایش صفحه اول مقاله
Novel poloxamer-based nanoemulsions to enhance the intestinal absorption of active compounds
چکیده انگلیسی

On the basis of Pluronic® P104 as primary emulsifier and Lauroglycol® 90 as amphiphilic oil phase, two nanoemulsion systems were developed with Pluronic® L62 or L81 as secondary emulsifiers. The possible nanoemulsion region of combinations of these excipients was described in ternary phase diagrams. Three formulations were selected from the nanoemulsion region and their potential impact on oral absorption was examined in the Caco-2 monolayer model of the small intestine. The apparent permeability of the BCS class III compound Atenolol was enhanced 2.5-fold, of BCS class II compound Danazol 3.2-fold and of BCS class I compound Metoprolol 1.4-fold. The three formulations were very well tolerated by the Caco-2 cells, which was confirmed by TEER measurements, a MTT test and a LDH release test.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Pharmaceutics - Volume 329, Issues 1–2, 1 February 2007, Pages 173–181
نویسندگان
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