کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2506611 1557524 2006 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Solid lipid nanoparticles incorporated in dextran hydrogels: A new drug delivery system for oral formulations
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی علوم دارویی
پیش نمایش صفحه اول مقاله
Solid lipid nanoparticles incorporated in dextran hydrogels: A new drug delivery system for oral formulations
چکیده انگلیسی

Solid lipid nanoparticles (SLN) containing or not (S)-(+)-2-(4-isobutylphenyl)propionic acid (ibuprofen) were prepared with Preciol ATO 5 as lipid phase by the hot homogenization technique and characterized through particle size analyses and zeta potential measurements. DSC experiments carried out on the freeze-dried samples of loaded SLN showed a shift of the melting endotherm of the lipid phase, with the maximum at a temperature value higher then that of the“empty” SLN. 1H NMR of the nanosuspension allowed to calculate the encapsulation efficiency of the particles that was 52 ± 3%. By adding dextran methacrylate (DEX-MA) to the aqueous phase and submitting the mixture to UV irradiation, systems of SLN (drug-loaded and unloaded) incorporated into a dextran hydrogel were prepared. Finally, dissolution studies of ibuprofen from the freeze-dried samples were performed. The comparison among the release profiles of ibuprofen from SLN, DEX-MA hydrogel and SLN/DEX-MA-hydrogel allows to affirm that this last system, retaining about 60% of the drug after 2 h in acid medium and releasing it slowly in neutral solution, is suitable for modified delivery oral formulations.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Pharmaceutics - Volume 325, Issues 1–2, 15 November 2006, Pages 140–146
نویسندگان
, , , , , , ,