کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2506613 1557524 2006 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Novel O-palmitoylscleroglucan-coated liposomes as drug carriers: Development, characterization and interaction with leuprolide
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی علوم دارویی
پیش نمایش صفحه اول مقاله
Novel O-palmitoylscleroglucan-coated liposomes as drug carriers: Development, characterization and interaction with leuprolide
چکیده انگلیسی

Polysaccharide-coated liposomes have been studied for their potential use for peptide drug delivery by the oral route because they are able to minimize the disruptive influences on peptide drugs of gastrointestinal fluids. The aim of this work was to synthesize and characterize a modified polysaccharide, O-palmitoylscleroglucan (PSCG), and to coate unilamellar liposomes for oral delivery of peptide drugs.To better evaluate the coating efficiency of PSCG, also scleroglucan (SCG)-coated liposomes were prepared.We studied the surface modification of liposomes and the SCG- and PSCG-coated liposomes were characterized in terms of size, shape, ζ potential, influence of polymer coating on bilayer fluidity, stability in serum, in simulated gastric and intestinal fluids and against sodium cholate and pancreatin.Leuprolide, a synthetic superpotent agonist of luteinizing hormone releasing hormone (LHRH) receptor, was chosen as a model peptide drug.After polymer coating the vesicle dimensions increased and the ζ potential shifted to less negative values. These results indicate that both SCG- and PSCG-coated liposomes surface and DSC results showed that PSCG was anchored on the liposomal surface.The stability of coated-liposomes in SGF, sodium cholate solution and pancreatin solution was increased.From this preliminary in vitro studies, it seems that PSCG-coated liposomes could be considered as a potential carrier for oral administration.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Pharmaceutics - Volume 325, Issues 1–2, 15 November 2006, Pages 155–162
نویسندگان
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