کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2506689 | 1557527 | 2006 | 8 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Compressed mini-tablets as a biphasic delivery system Compressed mini-tablets as a biphasic delivery system](/preview/png/2506689.png)
Compressed mini-tablets systems are presented as a biphasic delivery system designed for zero-order sustained drug release. The outer layer that fills the void spaces between the mini-tablets was formulated to release the drug in a very short time (fast release), while the mini-tablets provided a prolonged release. Different composition (HPMC or EC) and number (10 or 21) of mini-tablets were used to obtain different drug release rates. The in vitro performance of these systems showed the desired biphasic behaviour: the drug contained in the fast releasing phase (powder enrobing the mini-tablets) dissolved within the first 2 min, whereas the drug contained in the mini-tablets was released at different rates, depending up on formulation. Based on the release kinetic parameters calculated, it can be concluded that mini-tablets containing HPMC were particularly suitable approaching to zero-order (constant) release over 8 h time periods.
Journal: International Journal of Pharmaceutics - Volume 323, Issues 1–2, 12 October 2006, Pages 93–100