کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2506976 1557540 2006 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Betamethasone-in-cyclodextrin-in-liposome: The effect of cyclodextrins on encapsulation efficiency and release kinetics
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی علوم دارویی
پیش نمایش صفحه اول مقاله
Betamethasone-in-cyclodextrin-in-liposome: The effect of cyclodextrins on encapsulation efficiency and release kinetics
چکیده انگلیسی

Lipophilic drugs have limited solubility in phospholipid systems, hence maximum entrapment levels in liposomes are known to be low. “Drugs-in-cyclodextrin-in-liposome” systems were previously proposed to overcome this drawback but studies were limited to βCD and HPβCD. In some cases, other cyclodextrins may be more interesting than βCD or HPβCD, such as methylated cyclodextrins. However, these cyclodextrins are known to extract lipid components from the lipid membrane, which may destabilize liposomes.We tested the influence of several cyclodextrins (βCD, γCD, Dimeb, Trimeb, Crysmeb, Rameb, HPβCD and HPγCD) on the aqueous solubility of betamethasone by phase solubility diagrams and on the encapsulation efficiency in liposomes. The release kinetics of betamethasone was studied using Franz diffusion cells. We showed that release kinetics are directly correlated with encapsulation efficiency, which is closely related to betamethasone concentration in cyclodextrin complex solution. No liposome destruction was observed, even with the testing of methylated cyclodextrins at the highest concentration (40 mM). This can be explained by the fact that these cyclodextrins have a higher affinity for betamethasone than for cholesterol. This was proved by the comparison of phase solubility diagrams of both betamethasone and cholesterol.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Pharmaceutics - Volume 312, Issues 1–2, 7 April 2006, Pages 75–82
نویسندگان
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