کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2507119 1557543 2006 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Epitaxial 2D nucleation of the stable polymorphic form of the steroid 7αMNa on the metastable form: Implications for Ostwald's rule of stages
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی علوم دارویی
پیش نمایش صفحه اول مقاله
Epitaxial 2D nucleation of the stable polymorphic form of the steroid 7αMNa on the metastable form: Implications for Ostwald's rule of stages
چکیده انگلیسی

This paper presents in situ observations of the epitaxial nucleation and growth of the stable polymorph of a steroid, 7αMna, on a specific face of the metastable form at low supersaturation, using optical microscopy and in situ Raman spectroscopy. The presence of the metastable polymorph is essential for the nucleation and growth of the stable one. The order of the metastable zones of the stable and metastable polymorphs is reversed for the epitaxial growth process as compared to the case of 3D nucleation. The rate of transformation of the metastable polymorph to the stable one can be controlled by the supersaturation.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Pharmaceutics - Volume 309, Issues 1–2, 17 February 2006, Pages 16–24
نویسندگان
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