کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2507630 1557728 2016 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Graphene quantum dot modified glassy carbon electrode for the determination of doxorubicin hydrochloride in human plasma
ترجمه فارسی عنوان
الکترودهای کربن شیشه ای کریستال گرافن برای تعیین دوکوروبیکین هیدروکلراید در پلاسمای انسان؟
کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی علوم دارویی
چکیده انگلیسی

Low toxic graphene quantum dot (GQD) was synthesized by pyrolyzing citric acid in alkaline solution and characterized by ultraviolet--visible (UV–vis) spectroscopy, X-ray diffraction (XRD), atomic force microscopy (AFM), spectrofluorimetery and dynamic light scattering (DLS) techniques. GQD was used for electrode modification and electro-oxidation of doxorubicin (DOX) at low potential. A substantial decrease in the overvoltage (−0.56 V) of the DOX oxidation reaction (compared to ordinary electrodes) was observed using GQD as coating of glassy carbon electrode (GCE). Differential pulse voltammetry was used to evaluate the analytical performance of DOX in the presence of phosphate buffer solution (pH 4.0) and good limit of detection was obtained by the proposed sensor. Such ability of GQD to promote the DOX electron-transfer reaction suggests great promise for its application as an electrochemical sensor.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Analysis - Volume 6, Issue 4, August 2016, Pages 235–241
نویسندگان
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