کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2507806 1117509 2013 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Development and validation of a stability indicating RP-HPLC method for the determination of Rufinamide
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی علوم دارویی
پیش نمایش صفحه اول مقاله
Development and validation of a stability indicating RP-HPLC method for the determination of Rufinamide
چکیده انگلیسی

A stability-indicating RP-HPLC method was developed and validated for the determination of Rufinamide in tablet dosage forms using C 18 column (250 mm×4.6 mm, 5 μm) with mobile phase consisting of water–acetonitrile (40:60, v/v) with a flow rate of 0.8 mL/min (UV detection 215 nm). Linearity was observed over the concentration range 1.0–200 μg/mL (R2=0.9997) with regression equation y=113190 x+63053. Rufinamide was subjected to stress conditions including acidic, alkaline, oxidation, photolysis and thermal degradation. Rufinamide is more sensitive towards acidic degradation. The method was validated as per ICH guidelines.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Analysis - Volume 3, Issue 1, February 2013, Pages 66–70
نویسندگان
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