کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2509405 1117663 2015 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Why sildenafil and sildenafil citrate monohydrate crystals are not stable?
ترجمه فارسی عنوان
چرا کریستالهای سیلدنافیل و سیلدنافیل سیترات منوهیدرات پایدار نیستند؟
کلمات کلیدی
سیلدنافیل، سیلدنافیل سیترات مونوهیدرات، کریستالیزاسیون محلول، افزودن ضد حلال، تبخیر حلال آهسته، ثبات
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی علوم دارویی
چکیده انگلیسی

Sildenafil citrate was crystallized by various techniques aiming to determine the behavior and factors affecting the crystal growth. There are only 2 types of sildenafil obtaining from crystallization: sildenafil (1) and sildenafil citrate monohydrate (2). The used techniques were (i) crystallization from saturated solutions, (ii) addition of an antisolvent, (iii) reflux and (iv) slow solvent evaporation method. By pursuing these various methods, our work pointed that the best formation of crystal (1) was obtained from technique no. (i). Surprisingly, the obtained crystals (1) were perfected if the process was an acidic pH at a cold temperature then perfect crystals occurred within a day. Crystals of compound (2) grew easily using technique no. (ii) which are various polar solvents over a wide range of pH and temperature preparation processes. The infrared spectroscopy and nuclear magnetic resonance spectra fit well with these two X-ray crystal structures. The crystal structures of sildenafil free base and salt forms were different from their different growing conditions leading to stability difference.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Saudi Pharmaceutical Journal - Volume 23, Issue 5, October 2015, Pages 504–514
نویسندگان
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