Leptin levels in relation to marital status and neuroendocrine function in Iraqi females with polycystic ovary syndrome

The present study was designed to evaluate the relationship between serum leptin levels and the hormones related to fertility in Iraqi females with polycystic ovary syndrome (PCOS) and marital status. This study was conducted during the period from July to December 2007. Twenty-four women (12 married and 12 unmarried) with PCOS and not maintained on any type of therapy were included in the study. Twelve healthy and normal ovulatory women with an age range matched with that of PCOS women were included. After an overnight fasting, blood samples were drawn from all women at random days. While in those with regular menstrual cycles, blood samples were obtained during the follicular phase of the cycle, except for samples utilized for the assay of progesterone that performed in the day 21 of the cycle (luteal phase). After preparation of serum, the levels of leptin, luteinizing hormone (LH), follicle-stimulation hormone (FSH), progesterone, testosterone and prolactin were analyzed. Both groups of PCOS patients showed significantly lower levels of serum leptin, while prolactin, LH and FSH and testosterone were significantly elevated compared to controls. No significant differences were reported among PCOS patients with different marital status. In conclusion, impaired plasma leptin levels in PCOS women were associated with impaired endocrinological parameters related to fertility.