کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2509686 1117681 2009 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Evaluation of clinical activity and safety of Daflon 500 mg in type 2 diabetic female patients
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی علوم دارویی
پیش نمایش صفحه اول مقاله
Evaluation of clinical activity and safety of Daflon 500 mg in type 2 diabetic female patients
چکیده انگلیسی

BackgroundThe incidence of cardiovascular disease in patients with type 2 diabetes mellitus is approximately twice as high as in the non-diabetic population.AimTo investigate the hypoglycemic and hypocholesterolemic effects of Daflon® 500 mg (DF) administration together with its tolerability and efficacy in reducing the cardiovascular metabolic risk factors in female patients with type 2 diabetes.MethodsIn a well-adequate controlled single-blinded randomized parallel design the tolerability and the efficacy of Daflon® (500 mg) either alone or with oral hypoglycemic, twice daily for 45 days, was studied in 36 female patients with type 2 diabetes.ResultsNone of the patients in the studied groups were reported to have any adverse events throughout the treatment period (45 days), liver and kidney function tests were within normal limits and there was no significant difference between the pre-treatment (day 0) and post-treatment (day 45) values. Female patients receiving Daflon® either alone or with oral hypoglycemic showed significant decrease in serum glucose; fructosamine; total cholesterol; LDL–cholesterol; triglycerides; malondialdehydes (as index of lipid peroxidation) and C-reactive protein (CRB) levels along with increase in the levels of nitric oxide and blood glutathione.ConclusionThis study has shown that Daflon® (500 mg, twice daily for 45 days) is helpful in reducing glucose level and the risk of cardiovascular disease in type 2 diabetic patients.RecommendationFurther clinical trials are essential for strengthening the evidence base on the role of this drug in the cardiovascular risk in diabetic patients.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Saudi Pharmaceutical Journal - Volume 17, Issue 3, July 2009, Pages 199–207
نویسندگان
, ,