Synthesis and anti-histaminic activity of some novel pyrimidines

Novel pyrimidines were prepared by the condensation of chalcones of 4′-piperazine acetophenone with guanidine HCl. The structures of the synthesized compounds RP 1–5 were assigned on the basis of elemental analysis, IR, 1H NMR and mass spectroscopy. These compounds were also screened for anti-histaminic activity. The recorded percentage of histamine inhibition showed a significant anti-histaminic activity when compared to the reference anti-histaminic drug mepiramine.