کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2511380 1118017 2007 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The emergence of adamantane resistance in influenza A(H1) viruses in Australia and regionally in 2006
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ویروس شناسی
پیش نمایش صفحه اول مقاله
The emergence of adamantane resistance in influenza A(H1) viruses in Australia and regionally in 2006
چکیده انگلیسی

The adamantanes (amantadine and rimantadine) were the first antivirals licensed for use against influenza A viruses and have been used in some countries to control seasonal influenza. While increasing resistance of A(H3) viruses to this class of drug has been reported in recent years, only low levels of resistance were seen with A(H1) viruses until the 2005–2006 influenza season in the USA. In this study we analysed 101 human influenza A viruses isolated in 2006 that were referred to the WHO Collaborating Centre for Reference and Research in Melbourne, from Australia and the surrounding regions, for evidence of resistance to adamantanes. We found that whereas previously A(H1) resistant viruses were rare, 21.8% of the 2006 viruses had a resistant genotype. By comparison, 58.6% of influenza A(H3) viruses isolated in 2006 that were tested at the Centre, had a resistant genotype.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Antiviral Research - Volume 75, Issue 2, August 2007, Pages 173–176
نویسندگان
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