کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2511519 1118021 2006 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Effects of cidofovir treatment on cytokine induction in murine models of cowpox and vaccinia virus infection
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ویروس شناسی
پیش نمایش صفحه اول مقاله
Effects of cidofovir treatment on cytokine induction in murine models of cowpox and vaccinia virus infection
چکیده انگلیسی
Cytokine profiles during cowpox and vaccinia (WR strain) virus infections were characterized in intranasal (i.n.) and intraperitoneal (i.p.) models in BALB/c mice. The time-course of induction and effects of cidofovir treatment on interferon (IFN)-γ, IFN-γ inducible protein (IP)-10, interleukin (IL)-6, and monocyte chemoattractant protein (MCP)-1 were determined. The four mouse infection models have distinct patterns of cytokine induction. Cowpox virus i.p. and vaccinia virus i.n. infections showed increased induction throughout the time studied. Cowpox virus i.n. infection resulted in delayed induction of IFN-γ and IP-10. Cytokine levels were fairly constant during vaccinia virus i.p. infections. Cidofovir treatment (100 mg/kg/day i.p. for 2 days) significantly suppressed certain cytokine (IFN- γ, IL-6, IL-10, IL-11, IP-10, LIF, MCP-1, MCP-3, MCP-5, MIP-1γ, and TIMP-1) levels to near normal relative to uninfected animals, as well as prevented mortality and reduced virus titers significantly. Characterization of cytokine responses has implications for understanding the immune responses and pathogeneses of viral infections in these mouse models.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Antiviral Research - Volume 72, Issue 2, November 2006, Pages 125-133
نویسندگان
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