کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2512008 1118308 2015 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Cigarettes and alcohol: The influence of nicotine on operant alcohol self-administration and the mesolimbic dopamine system
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی داروشناسی
پیش نمایش صفحه اول مقاله
Cigarettes and alcohol: The influence of nicotine on operant alcohol self-administration and the mesolimbic dopamine system
چکیده انگلیسی

Studies in human populations consistently demonstrate an interaction between nicotine and ethanol use, each drug influencing the use of the other. Here we present data and review evidence from animal studies that nicotine influences operant self-administration of ethanol. The operant reinforcement paradigm has proven to be a behaviorally relevant and quantitative model for studying ethanol-seeking behavior. Exposure to nicotine can modify the reinforcing properties of ethanol during different phases of ethanol self-administration, including acquisition, maintenance, and reinstatement. Our data suggest that non-daily intermittent nicotine exposure can trigger a long-lasting increase in ethanol self-administration. The biological basis for interactions between nicotine and ethanol is not well understood but may involve the stress hormone systems and adaptations in the mesolimbic dopamine system. Future studies that combine operant self-administration with techniques for monitoring or manipulating in vivo neurophysiology may provide new insights into the neuronal mechanisms that link nicotine and alcohol use.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical Pharmacology - Volume 97, Issue 4, 15 October 2015, Pages 550–557
نویسندگان
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