کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2513856 1118438 2009 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Nicotinic acetylcholine receptors and the ascending dopamine pathways
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی داروشناسی
پیش نمایش صفحه اول مقاله
Nicotinic acetylcholine receptors and the ascending dopamine pathways
چکیده انگلیسی

Nicotinic acetylcholine receptors (nAChRs) are widely expressed in midbrain dopamine neurons that project to dorsal striatum, nucleus accumbens and prefrontal cortex. Thus nAChRs can influence the functions of these three pathways, notably motor control, ‘reward’ and executive function, respectively. Diverse subtypes of nAChRs have been identified on dopamine cell bodies and terminals as well as on neighbouring afferents and interneurons. Here we review the molecular and cellular mechanisms through which nAChRs exert their influence on these pathways in rodents.

Nicotinic acetylcholine receptors (nAChRs) affect dopamine cell firing and release probability in three major ascending pathways; nigrostriatal, mesolimbic and mesocortical. nAChRs are therefore poised to modulate multiple brain functions.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical Pharmacology - Volume 78, Issue 7, 1 October 2009, Pages 744–755
نویسندگان
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