کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2514555 1118472 2008 13 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Molecular mechanism of L-DNase II activation and function as a molecular switch in apoptosis
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی داروشناسی
پیش نمایش صفحه اول مقاله
Molecular mechanism of L-DNase II activation and function as a molecular switch in apoptosis
چکیده انگلیسی

The discovery of caspase activation counts as one of the most important finds in the biochemistry of apoptosis. However, targeted disruption of caspases does not impair every type of apoptosis. Other proteases can replace caspases and several so called “caspase independent” pathways are now described. Here we review our current knowledge on one of these pathways, the LEI/L-DNase II. It is a serine protease-dependent pathway and its key event is the transformation of LEI (leukocyte elastase inhibitor, a serine protease inhibitor) into L-DNase II (an endonuclease). The molecular events leading to this change of enzymatic function as well as the cross-talk and interactions of this molecule with other apoptotic pathway, including caspases, are discussed.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical Pharmacology - Volume 76, Issue 11, 1 December 2008, Pages 1490–1502
نویسندگان
, , , , ,