کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2514723 | 1118480 | 2007 | 10 صفحه PDF | دانلود رایگان |
The cloning of the histamine H3 receptor (H3R) cDNA in 1999 by Lovenberg et al. [10] allowed detailed studies of its molecular aspects and indicated that the H3R can activate several signal transduction pathways including Gi/o-dependent inhibition of adenylyl cyclase, activation of phospholipase A2, Akt and the mitogen activated kinase as well as the inhibition of the Na+/H+ exchanger and inhibition of K+-induced Ca2+ mobilization. Moreover, cloning of the H3R has led to the discovery several H3R isoforms generated through alternative splicing of the H3R mRNA.The H3R has gained the interest of many pharmaceutical companies as a potential drug target for the treatment of various important disorders like obesity, myocardial ischemia, migraine, inflammatory diseases and several CNS disorders like Alzheimer's disease, attention-deficit hyperactivity disorder and schizophrenia.In this paper, we review various molecular aspects of the hH3R including its signal transduction, dimerization and the occurrence of different H3R isoforms.
Journal: Biochemical Pharmacology - Volume 73, Issue 8, 15 April 2007, Pages 1195–1204