کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2515291 1118511 2008 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Physiological and pharmacokinetic roles of H+/organic cation antiporters (MATE/SLC47A)
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی داروشناسی
پیش نمایش صفحه اول مقاله
Physiological and pharmacokinetic roles of H+/organic cation antiporters (MATE/SLC47A)
چکیده انگلیسی

Vectorial secretion of cationic compounds across tubular epithelial cells is an important function of the kidney. This uni-directed transport is mediated by two cooperative functions, which are membrane potential-dependent organic cation transporters at the basolateral membranes and H+/organic cation antiporters at the brush-border membranes. More than 10 years ago, the basolateral organic cation transporters (OCT1-3/SLC22A1-3) were isolated, and molecular understandings for the basolateral entry of cationic drugs have been greatly advanced. However, the molecular nature of H+/organic cation antiport systems remains unclear. Recently, mammalian orthologues of the multidrug and toxin extrusion (MATE) family of bacteria have been isolated and clarified to function as H+/organic cation antiporters. In this commentary, the molecular characteristics and pharmacokinetic roles of mammalian MATEs are critically overviewed focusing on the renal secretion of cationic drugs.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical Pharmacology - Volume 75, Issue 9, 1 May 2008, Pages 1689–1696
نویسندگان
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