کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2524047 | 1557967 | 2015 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
MiR-661 contributed to cell proliferation of human ovarian cancer cells by repressing INPP5J expression
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موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
تومور شناسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: MiR-661 contributed to cell proliferation of human ovarian cancer cells by repressing INPP5J expression MiR-661 contributed to cell proliferation of human ovarian cancer cells by repressing INPP5J expression](/preview/png/2524047.png)
چکیده انگلیسی
Accumulating evidence has emerged important roles for microRNAs (miRNAs) participating in oncogenesis and growth of various cancers. We hypothesized that miR-661 played an important role in cell growth of ovarian cancer. Here, we found miR-661 was upregulated in human ovarian cancer cell lines and clinical tumor tissues. Our results revealed that miR-661 directly targeted INPP5J, thereby acting as tumor promoter in ovarian cancer cells by blocking cell proliferation. Importantly, we identified miR-661 as a positive regulator of INPP5J-induced AKT pathway. Taken together, our study sheds light onto the role of miR-661 as tumor promoter by targeting the INPP5J gene, and then promoting cell proliferation of ovarian cancer.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biomedicine & Pharmacotherapy - Volume 75, October 2015, Pages 123–128
Journal: Biomedicine & Pharmacotherapy - Volume 75, October 2015, Pages 123–128
نویسندگان
Tongyu Zhu, Jing Yuan, Yuzhi Wang, Cuiping Gong, Yudou Xie, Hong Li,