کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2524268 1119552 2014 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Enhancement of the antibiotic activity of aminoglycosides by alpha-tocopherol and other cholesterol derivates
ترجمه فارسی عنوان
تقویت فعالیت آنتی بیوتیک آمینوگلیکوزید توسط آلفا توکوفرول و سایر مشتقات کلسترول
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی تومور شناسی
چکیده انگلیسی

Alpha-tocopherol, one of the most abundant isoforms of vitamin E, is a biologically active liposoluble vitamin and potent antioxidant. It occurs naturally in foods of plant and animal origin. Because of its lipophilic character, it can cause perturbations in the bacterial cell membrane, resulting in damage to components essential for the integrity of the membrane, thereby allowing an increase in permeability. This is the first report of the modulatory effect of alpha-tocopherol in multiresistant bacteria. We evaluated alpha-tocopherol against multiresistant strains of Staphylococcus aureus, Pseudomonas aeruginosa and Escherichia coli, and determined if there was any similarity with the mechanism of modulatory action of cholesterol and ergosterol. When combined with aminoglycosides in a microdilution broth assay, alpha-tocopherol possibly acted through a lipophilic action on the cell envelope, modulating more effectively P. aeruginosa and E. coli, when compared with S. aureus.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biomedicine & Pharmacotherapy - Volume 68, Issue 8, October 2014, Pages 1065–1069
نویسندگان
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