کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2524691 | 1557959 | 2016 | 11 صفحه PDF | دانلود رایگان |

Various formulations of anise-based bioadhesive gels are prepared. Freeze-drying method was successfully employed and superporous scaffolds were obtained. The resulting porous microarchitectures are strongly influenced by the composition of hydrogel formulations and temperature of freezing. Anise-based hydrogels frozen in liquid nitrogen and lyophilized generate regular assembly of polyhedral pores. For Carbopol 934-based hydrogels it was determined G′ > G′′ for whole tested strain amplitude range indicating solid-like behaviour due to their dense network and entanglement and interaction through hydrogen bonds and van-der Waals forces. For sodium alginate-based hydrogels it was determined G′′ > G′ for whole tested strain amplitude range accompanied by the extended linear viscoelastic region indicating liquid-like behaviour due to the formation of a stable “pseudo-gel” structure. Biocompatibility features of tested hydrogels were evaluated by contact angle measurements and determination of surface tension parameters. It was found that all anise-based hydrogel formulations manifest modest activity against S. aureus and S. lutea and no activity against tested Gram negative bacteria. Carbopol 934-based hydrogels containing anise exhibit antifungal activity against C. albicans, C. glabrata and C. Parapsilosis.
Journal: Biomedicine & Pharmacotherapy - Volume 83, October 2016, Pages 485–495