کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2525100 | 1119595 | 2013 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Initiation of apoptosis, cell cycle arrest and autophagy of esophageal cancer cells by dihydroartemisinin
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
تومور شناسی
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چکیده انگلیسی
Dihydroartemisinin (DHA) has recently been shown anti-tumor activity in various cancer cells. However, its effect on esophageal cancer remains unclear. In this study, for the first time, we demonstrated that DHA reduced viability of esophageal cancer cells in a dose-dependent manner. The mechanism was at least partially due to DHA induced apoptosis by upregulating the expression of Bax, downregulating Bcl-2, Bcl-xL and Procaspase-3, and increasing caspase-9 activation, induced cell cycle arrest by downregulating cyclin E, CDK2 and CDK4. Furthermore, we firstly found that DHA induced autophagy in cancer cells. We concluded DHA might be a novel agent against esophageal cancer.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biomedicine & Pharmacotherapy - Volume 67, Issue 5, June 2013, Pages 417–424
Journal: Biomedicine & Pharmacotherapy - Volume 67, Issue 5, June 2013, Pages 417–424
نویسندگان
Xiao-Xue Du, Yan-Jing Li, Chun-Long Wu, Jian-Hua Zhou, Yu Han, Hong Sui, Xiao-Li Wei, Lei Liu, Peng Huang, Heng-Heng Yuan, Ting-Ting Zhang, Wen-Jie Zhang, Rui Xie, Xiao-Hui Lang, De-Xin Jia, Yu-Xian Bai,