کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2525409 | 1119611 | 2009 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Synthesis and biological evaluation of decavanadate Na4Co(H2O)6V10O28·18H2O
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
تومور شناسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Synthesis and biological evaluation of decavanadate Na4Co(H2O)6V10O28·18H2O Synthesis and biological evaluation of decavanadate Na4Co(H2O)6V10O28·18H2O](/preview/png/2525409.png)
چکیده انگلیسی
We have reported the synthesis and biological evaluation of a decavanadate Na4Co(H2O)6V10O28·18H2O (CoV10) designed as a potential antitumoral agent. The human cancer cell lines SMMC-7721 (liver cancer) and SK-OV-3 (ovary cancer) were tested for their viability by the MTT method in vitro, which showed that the compound exhibited a remarkable activity against two cell lines with IC50 values smaller than 0.24 μg/mL, 0.32 μg/mL, respectively. CoV10 showed the tumor growth suppression for Hep-A-22 (mice liver cancer) in tumor bearing mice in vivo. In addition, using flow cytometry analysis, the ratio of apoptotic cells was up to 8.33% with treatment of CoV10 at 1.56 μg/mL after 30 min, suggesting that the antitumoral activity of CoV10 comes from the activation of the apoptotic pathway.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biomedicine & Pharmacotherapy - Volume 63, Issue 1, January 2009, Pages 51-55
Journal: Biomedicine & Pharmacotherapy - Volume 63, Issue 1, January 2009, Pages 51-55
نویسندگان
Fengying Zhai, Xiaohong Wang, Dongliu Li, He Zhang, Rui Li, Liansheng Song,