کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2525717 | 1119626 | 2008 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Enhancing effects of new biological response modifier β-1,3 glucan sulfate PS3 on immune reactions
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
تومور شناسی
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چکیده انگلیسی
Glucans have a long history as non-specific biological modulators; however, but the search for optimal chemical configuration is still on. The objective of this study was to evaluate intraperitoneal application of PS3, a sulfated derivative of a (1–>3)-β-d-glucan isolated from sporophytes of Laminaria digitata. PS3 showed significant stimulation of phagocytic activity as well as potentiation of synthesis and release of IL-2 by splenocytes. In addition, PS3 increased NK cell-mediated killing of tumor cells both in vitro and in vivo. When combined, our observations suggest that PS3 is similarly effective as native non-sulfated (1–>3)-β-d-glucan and is generally more active than lentinan.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biomedicine & Pharmacotherapy - Volume 62, Issue 5, June 2008, Pages 283–288
Journal: Biomedicine & Pharmacotherapy - Volume 62, Issue 5, June 2008, Pages 283–288
نویسندگان
Vaclav Vetvicka, Jana Vetvickova, Jamois Frank, Jean-Claude Yvin,