کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2525717 1119626 2008 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Enhancing effects of new biological response modifier β-1,3 glucan sulfate PS3 on immune reactions
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی تومور شناسی
پیش نمایش صفحه اول مقاله
Enhancing effects of new biological response modifier β-1,3 glucan sulfate PS3 on immune reactions
چکیده انگلیسی

Glucans have a long history as non-specific biological modulators; however, but the search for optimal chemical configuration is still on. The objective of this study was to evaluate intraperitoneal application of PS3, a sulfated derivative of a (1–>3)-β-d-glucan isolated from sporophytes of Laminaria digitata. PS3 showed significant stimulation of phagocytic activity as well as potentiation of synthesis and release of IL-2 by splenocytes. In addition, PS3 increased NK cell-mediated killing of tumor cells both in vitro and in vivo. When combined, our observations suggest that PS3 is similarly effective as native non-sulfated (1–>3)-β-d-glucan and is generally more active than lentinan.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biomedicine & Pharmacotherapy - Volume 62, Issue 5, June 2008, Pages 283–288
نویسندگان
, , , ,