کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2542631 | 1122718 | 2007 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
RNA interference as a novel and powerful tool in immunopharmacological research
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: RNA interference as a novel and powerful tool in immunopharmacological research RNA interference as a novel and powerful tool in immunopharmacological research](/preview/png/2542631.png)
چکیده انگلیسی
RNA interference (RNAi), as an evolutionarily conserved mechanism for silencing gene expression, is realized through the actions of both small interference RNA (siRNA) and microRNA. Since its discovery, siRNA has been rapidly deployed not only for the elucidation of gene function, but also for identification of drug targets and as a powerful therapeutic approach for a variety of diseases. In this review, we briefly introduce the mechanisms of RNAi, methods of siRNA design and delivery, and summarized recent researches on the therapeutic potential of RNAi for immune diseases.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Immunopharmacology - Volume 7, Issue 4, April 2007, Pages 417–426
Journal: International Immunopharmacology - Volume 7, Issue 4, April 2007, Pages 417–426
نویسندگان
Yan Kong, Lingfei Ruan, Lili Ma, Youhong Cui, Ji Ming Wang, Yingying Le,