کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2545800 | 1124005 | 2011 | 9 صفحه PDF | دانلود رایگان |
Ethnopharmacological relevanceThe present study investigates the protective effects of water extract of ginseng (Panax ginseng C.A. Meyer) against 1-methyl-4-phenylpyridinium ion (MPP+)-induced cytotoxicity in SH-SY5Y human neuroblastoma cells and explores the underlying mechanisms. The approach may be used for screening therapeutic agents for degenerative disorders such as Parkinson's disease.Materials and methodsSH-SY5Y human neuroblastoma cells were used to analyze the protective effects of water extract of ginseng (WEG) against multiple parameters such as MPP+-induced viability, oxidative injury, expression of Bax, Bcl-2, cytochrome c and cleaved caspase-3.ResultsWEG exerted inhibitory effect on cell death, overproduction of ROS, elevated Bax/Bcl-2 ratio, release of cytochrome c and activation of caspase-3 expression in MPP+-treated SH-SY5Y cells.ConclusionsWEG exhibited significant protective effects against MPP+-induced cytotoxicity in SH-SY5Y cells possibly through the suppression of ROS generation and the inhibition of mitochondria-dependent apoptotic pathway.
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Journal: Journal of Ethnopharmacology - Volume 135, Issue 1, 26 April 2011, Pages 34–42