کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2546107 | 1560408 | 2010 | 7 صفحه PDF | دانلود رایگان |
Aim of the studyEighteen plants were assessed for antimicrobial activity against pathogens associated with prevalent urogenital/sexually transmitted infections. Plant selection was based on information obtained from the ethnobotanical literature.Materials and methodsDried plant material was submerged in a 1:1 mixture of methanol and dichloromethane for 24 h. Aqueous extracts were prepared by submerging dried plant material in sterile distilled water for 24 h followed by lyophilization. Essential oils were distilled from the two aromatic plant species (Tarchonanthus camphoratus and Croton gratissimus). Antimicrobial activity was assessed using the micro-well minimum inhibitory concentration (MIC) assay with specific modifications to facilitate fastidious growth of pathogens.ResultsTarchonanthus camphoratus (solvent extract) showed the most significant broad spectrum activity with MIC values ranging between 0.50 and 0.70 mg/ml against five of the six pathogens tested. Other noteworthy activity was found for Hypericum aethiopicum (root) at 0.3 mg/ml (Neisseria gonorrhoeae).Polygala fruticosa and the solvent root extract of Hypericum aethiopicum showed highest sensitivities towards Gardnerella vaginalis at 0.2 mg/ml. Efficacy of the solvent extracts against the pathogen Oligella ureolytica demonstrated antimicrobial activity (MIC values ≤1.0 mg/ml) for seven plant species. The highest activity noted against Ureaplasma urealyticum was for Psidium guajava (solvent extract) at 0.8 mg/ml. In general the aqueous extracts displayed mostly poor anti-STI activity. The most noteworthy susceptibility for the aqueous extracts was noted with the plant extract Syzygium cordatum (MIC value 0.1 mg/ml against Candida albicans). The most noteworthy activity for the essential oils was observed for Tarchonanthus camphoratus (0.8 mg/ml) against Oligella ureolytica.ConclusionsAntimicrobial activity was observed for a number of the plant samples against at least one or more pathogen, thus validating the ethnobotanical use as an anti-infective to treat sexually transmitted diseases.
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Journal: Journal of Ethnopharmacology - Volume 130, Issue 3, 9 August 2010, Pages 552–558