کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2548369 1560411 2006 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Antiplasmodial activity and cytotoxicity of plants used in West African traditional medicine for the treatment of malaria
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی داروشناسی
پیش نمایش صفحه اول مقاله
Antiplasmodial activity and cytotoxicity of plants used in West African traditional medicine for the treatment of malaria
چکیده انگلیسی

Eighteen plants originating from Ivory Coast were selected by ethnobotanical survey as plants commonly used by traditional healers for the treatment of malaria. Extracts of these plants were tested on two strains of Plasmodium falciparum: FcM29-Cameroon (chloroquine-resistant strain) and a Nigerian chloroquine-sensitive strain. The powdered plants were used to prepare three kinds of extracts: by decoction in water, in ethanol (95%) and in pentane. A radioactive micromethod allowed the evaluation of the antiplasmodial in vitro activity of the extracts on P. falciparum. Concentrations inhibiting 50% of the parasite growth (IC50) ranged from 18 μg/ml to more than 500 μg/ml for aqueous and ethanol extracts and from 4.3 μg/ml to more than 500 μg/ml for pentane extracts. Cytotoxicity was estimated on A375 melanoma cells and a cytotoxicity/antiplasmodial index (CAR) was calculated for each extract, ranging from 1 to 10. The pentane extracts of Cola caricaefolia and Uvaria afzelii, which revealed the strongest antiplasmodial activity had CAR values of about 10.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Ethnopharmacology - Volume 105, Issues 1–2, 21 April 2006, Pages 131–136
نویسندگان
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