کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2548594 1124133 2006 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Neuropharmacological profile of an ethanol extract of Ruta chalepensis L. in mice
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی داروشناسی
پیش نمایش صفحه اول مقاله
Neuropharmacological profile of an ethanol extract of Ruta chalepensis L. in mice
چکیده انگلیسی

The effects of an ethanol extract of the aerial parts of Ruta chalepensis on the central nervous system (CNS) and LD50 determination were studied in mice. A crude extract was given systemically and its effects were tested on pentylenetetrazole (PTZ)-induced seizures, sodium pentobarbital-induced hypnosis, exploratory activity, anxiety and nociception. Results from the experimental models tested showed: (1) a delay in the onset of seizures and a dose-dependent suppression in the tonic phase and mortality induced by PTZ; (2) a prolongation of the time of sodium pentobarbital-induced hypnosis; (3) a significant attenuation in the anxiety-response and (4) a reduction in the licking time and shaking behavior in the formalin-induced nociception test. The sedative-hypnotic potentiation, anxiolytic, anticonvulsant and antinociceptive effects suggest that Ruta chalepensis induces a depressant activity on the CNS.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Ethnopharmacology - Volume 106, Issue 1, 15 June 2006, Pages 129–135
نویسندگان
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