کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2550413 1560571 2016 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Chronic intermittent hypobaric hypoxia antagonizes renal vascular hypertension by enhancement of vasorelaxation via activating BKCa
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
Chronic intermittent hypobaric hypoxia antagonizes renal vascular hypertension by enhancement of vasorelaxation via activating BKCa
چکیده انگلیسی

AimThe purpose of the present study was to explore anti-hypertensive effect of chronic intermittent hypobaric hypoxia (CIHH) in renovascular hypertension (RVH) rats, as well as the role of large-conductance calcium-activated potassium channel (BKCa) in anti-hypertensive effect of CIHH.Main methodsMale adult age- and body weight-matched Sprague-Dawley rats were divided into SHAM, CIHH, RVH and RVH + CIHH groups. Hypertension was induced by two-kidney-1-clip method (2K1C) in RVH rats. CIHH rats were exposed to 28-days hypobaric hypoxia simulating 5000 m altitude, 6 h daily. SHAM rats got an operation without 2K1C, and RVH + CIHH rats received CIHH treatment after 2K1C. The endothelium-dependent vasorelaxation induced by acetylcholine (ACh), BKCa currents in smooth muscle cells (VSMCs) of mesenteric arteries and the protein expression of BKCa in mesenteric arteries was examined.Key findingsThe systolic arterial blood pressure (SAP) in RVH rats was higher than that in SHAM rats and CIHH treatment significantly decreased SAP in RVH rats. The enhanced vasorelaxation of mesenteric artery in CIHH-treated RVH rats was cancelled by BKCa blocker IBTX. The vasorelaxation induced by BKCa activator was reduced in RVH rats and the decreased vasorelaxation was improved by CIHH treatment. The β1 subunit of BKCa in mesenteric artery was upregulated and BKCa current in VSMCs was increased in CIHH-treated RVH rats compared with RVH rats.SignificanceIn conclusion, CIHH treatment enhances the relaxation of mesenteric artery through activation of BKCavia up-regulating β1 subunit of BKCa, which might be one of mechanisms for anti-hypertensive effect of CIHH in RVH rats.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Life Sciences - Volume 157, 15 July 2016, Pages 74–81
نویسندگان
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