کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2550487 1560576 2016 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Air pollution and skin diseases: Adverse effects of airborne particulate matter on various skin diseases
ترجمه فارسی عنوان
آلودگی هوا و بیماری های پوستی: اثرات جانبی ذرات هوا در برابر بیماری های مختلف پوست
کلمات کلیدی
ذرات جامد، بیماری های التهابی پوست، پیری، آلوپسی، سرطان پوست، استرس اکسیداتیو، سیتوکین پروتئین التهابی
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
چکیده انگلیسی

Environmental air pollution encompasses various particulate matters (PMs). The increased ambient PM from industrialization and urbanization is highly associated with morbidity and mortality worldwide, presenting one of the most severe environmental pollution problems. This article focuses on the correlation between PM and skin diseases, along with related immunological mechanisms. Recent epidemiological studies on the cutaneous impacts of PM showed that PM affects the development and exacerbation of skin diseases. PM induces oxidative stress via production of reactive oxygen species and secretion of pro-inflammatory cytokines such as TNF-α, IL-1α, and IL-8. In addition, the increased production of ROS such as superoxide and hydroxyl radical by PM exposure increases MMPs including MMP-1, MMP-2, and MMP-9, resulting in the degradation of collagen. These processes lead to the increased inflammatory skin diseases and skin aging. In addition, environmental cigarette smoke, which is well known as an oxidizing agent, is closely related with androgenetic alopecia (AGA). Also, ultrafine particles (UFPs) including black carbon and polycyclic aromatic hydrocarbons (PAHs) enhance the incidence of skin cancer. Overall, increased PM levels are highly associated with the development of various skin diseases via the regulation of oxidative stress and inflammatory cytokines. Therefore, anti-oxidant and anti-inflammatory drugs may be useful for treating PM-induced skin diseases.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Life Sciences - Volume 152, 1 May 2016, Pages 126–134
نویسندگان
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