کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2550675 1560582 2016 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Comparison between electronic cigarette refill liquid and nicotine on metabolic parameters in rats
ترجمه فارسی عنوان
مقایسه مایع مجاز سیگار الکترونیکی و نیکوتین بر پارامترهای متابولیک در موش صحرایی
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
چکیده انگلیسی

AimsNicotine is known to promote body weight loss and to disturb glucose homeostasis and lipoprotein metabolism. Electronic cigarettes, as a substitute to nicotine, are becoming increasingly popular, although there is no evidence regarding their safety. Considering the dearth of information about e-cigarette toxicity, the present study was designed to compare nicotine alone to e-liquid with or without nicotine on metabolic parameters in Wistar rats.Main methodsFor this purpose, e-liquid with or without nicotine and nicotine alone (0.5 mg/kg of body weight) were administered intra-peritoneally during 28 days.Key findingsOur results show a significant decrease in food and energy intake after nicotine or e-liquid with nicotine exposure, when compared to control or e-liquid without nicotine. Analysis of lipid status identified a significant decrease in cholesterol and LDL levels in e-cigarette groups, suggesting an improvement in lipid profile. Interestingly, e-liquid without nicotine induced hyperglycemia which is negatively correlated to hepatic glycogen level, acting like nicotine alone. Furthermore, an increase in liver biomarkers was observed in all treated groups. qRT-PCR analysis showed GSK3β up-regulation in e-liquid with nicotine as well as, surprisingly, in e-liquid without nicotine exposure. In contrast, PEPCK genes were only up-regulated in e-liquid with nicotine.SignificanceWhile some features observed in rats may not be observed in human smokers, most of our data are consistent with, e-liquid per se i.e. without nicotine, not being neutral from a metabolic stand point since disrupting glucose homeostasis in rats.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Life Sciences - Volume 146, 1 February 2016, Pages 131–138
نویسندگان
, , , , , , , , , ,