کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2550788 1560588 2015 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
20 years of leptin: Role of leptin in cardiomyocyte physiology and physiopathology
ترجمه فارسی عنوان
20 ساله لپتین: نقش لپتین در فیزیولوژی و فیزیولوژی شناسی قلب و عروق
کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
چکیده انگلیسی

Since the discovery of leptin in 1994 by Zhang et al., there have been a number of reports showing its implication in the development of a wide range of cardiovascular diseases. However, there exists some controversy about how leptin can induce or preserve cardiovascular function, as different authors have found contradictory results about leptin beneficial or detrimental effects in leptin deficient/resistant murine models and in wild type tissue and cardiomyocytes. Here, we will focus on the main discoveries about the leptin functions at cardiac level within the last two decades, focusing on its role in cardiac metabolism, remodeling and contractile function.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Life Sciences - Volume 140, 1 November 2015, Pages 10–18
نویسندگان
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