کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2551008 1124687 2014 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The effects of methyl palmitate, a putative regulator from perivascular fat, on the contractility of pregnant human myometrium
ترجمه فارسی عنوان
اثرات متیل پالمیتات، یک تنظیم کننده احتمالی از چربی پریواسکولار، بر انقباض بیومتریوم باردار
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
چکیده انگلیسی

AimsMethyl palmitate is thought to cause relaxation in vascular smooth muscle by opening voltage-activated potassium channels. We have tested the hypothesis that methyl palmitate, a putative regulator from perivascular fat, is an inhibitor of the contractility of human pregnant myometrium and that its effects might partially explain the higher incidence of dysfunctional labor in obese women compared to those with normal body mass indices.Main methodsStrips of myometrium obtained with informed consent from women undergoing elective cesarean section at term were mounted in organ baths. Strips stimulated with oxytocin (1 nM) or KCl (30 mM) were exposed to cumulatively increasing concentrations of methyl palmitate up to 10 μM. Similar strips were exposed to cumulative addition of the potassium channel blockers 4-aminopyridine and tetraethylammonium. The contractility of the strips was monitored and analyzed using conventional methods.Key findingsMethyl palmitate failed to inhibit oxytocin- or KCl-induced contractions over the concentration range tested. In fact, it exerted a slight excitatory effect in the presence of KCl, though not in the presence of oxytocin. The contractility of naïve strips was unaltered by exposure to 1 μM methyl palmitate. Both 4-aminopyridine and tetraethylammonium produced concentration-dependent contractions of human pregnant myometrium providing pharmacological evidence for the presence of voltage-activated potassium channels in this preparation.SignificanceOur findings do not support the hypothesis that methyl palmitate is an inhibitor of human pregnant myometrial contractility. Alternate hypotheses must be pursued to explain the higher incidence of dysfunctional labor in obese women.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Life Sciences - Volume 116, Issue 1, 22 October 2014, Pages 25–30
نویسندگان
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