کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2551406 1124726 2014 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Resistance exercise acutely enhances mesenteric artery insulin-induced relaxation in healthy rats
ترجمه فارسی عنوان
تمرینات مقاومتی به شدت باعث آرامش ناشی از انسولین شرایین مزانتریک در موشهای سالم می شود
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
چکیده انگلیسی

AimsWe evaluated the mechanisms involved in insulin-induced vasodilatation after acute resistance exercise in healthy rats.Main methodsWistar rats were divided into 3 groups: control (CT), electrically stimulated (ES) and resistance exercise (RE). Immediately after acute RE (15 sets with 10 repetitions at 70% of maximal intensity), the animals were sacrificed and rings of mesenteric artery were mounted in an isometric system. After this, concentration–response curves to insulin were performed in control condition and in the presence of LY294002 (PI3K inhibitor), L-NAME (NOS inhibitor), L-NAME + TEA (K+ channels inhibitor), LY294002 + BQ123 (ET-A antagonist) or ouabain (Na+/K+ ATPase inhibitor).Key findingsAcute RE increased insulin-induced vasorelaxation as compared to control (CT: Rmax = 7.3 ± 0.4% and RE: Rmax = 15.8 ± 0.8%; p < 0.001). NOS inhibition reduced (p < 0.001) this vasorelaxation from both groups (CT: Rmax = 2.0 ± 0.3%, and RE: Rmax = − 1.2 ± 0.1%), while PI3K inhibition abolished the vasorelaxation in CT (Rmax = − 0.1 ± 0.3%, p < 0.001), and caused vasoconstriction in RE (Rmax = − 6.5 ± 0.6%). That insulin-induced vasoconstriction on PI3K inhibition was abolished (p < 0.001) by the ET-A antagonist (Rmax = 2.9 ± 0.4%). Additionally, acute RE enhanced (p < 0.001) the functional activity of the ouabain-sensitive Na+/K+ ATPase activity (Rmax = 10.7 ± 0.4%) and of the K+ channels (Rmax = − 6.1 ± 0.5%; p < 0.001) in the insulin-induced vasorelaxation as compared to CT.SignificanceSuch results suggest that acute RE promotes enhanced insulin-induced vasodilatation, which could act as a fine tuning to vascular tone.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Life Sciences - Volume 94, Issue 1, 14 January 2014, Pages 24–29
نویسندگان
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