کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2551484 1124733 2013 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Macelignan attenuated allergic lung inflammation and airway hyper-responsiveness in murine experimental asthma
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
Macelignan attenuated allergic lung inflammation and airway hyper-responsiveness in murine experimental asthma
چکیده انگلیسی

AimsMacelignan isolated from Myristica fragrans Houtt. is widely used for spice and flavoring for foods, and has been reported to have anti-inflammatory activity. The aim of this study was to investigate the effects of macelignan on allergic lung inflammation with a murine model of experimental asthma.Main methodsFungal protease mixed with chicken egg ovalbumin allergen was used as a challenge to induce murine experimental asthma. To determine its effects on allergy and inflammation, macelignan was administered orally during allergen challenge, and the symptoms of allergic asthma and its underlined mechanisms were examined.Key findingsTreatment with macelignan attenuated eosinophilic airway inflammation and airway hyper-responsiveness. With the administration of macelignan, interleukin-4 (IL-4) producing cells, but not interferon-γ (IFN-γ) or IL-17 producing cells, were diminished in the lungs. Additionally, activation of the T helper type 2 (Th2) cell-specific master transcription factor, GATA3 was decreased with macelignan treatment. Finally, production of IL-4 but not IFN-γ or IL-17, by CD4+ T cells was reduced with stimulation when combined with the administration of macelignan.SignificanceOur data show that macelignan has anti-inflammatory effects on Th2 cell-mediated allergic lung inflammation and could potentially provide a novel preventative and/or therapy for the treatment of allergic diseases.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Life Sciences - Volume 92, Issue 22, 13 June 2013, Pages 1093–1099
نویسندگان
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