کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2552359 1560703 2010 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Association of signal transducer and activator of transcription 4 genetic variants with extra-intestinal manifestations in inflammatory bowel disease
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
Association of signal transducer and activator of transcription 4 genetic variants with extra-intestinal manifestations in inflammatory bowel disease
چکیده انگلیسی

AimsThe STAT4 gene encodes a transcription factor which plays an important role in the development of inflammation of many immune-mediated diseases. We investigated the relationship between STAT4 single nucleotide polymorphisms (SNPs) and susceptibility to ulcerative colitis (UC) and Crohn's disease (CD) and disease phenotypes in the Korean population.Main methodsWe performed a case–control association study in individuals with UC (N = 246), CD (N = 182), and healthy controls (N = 229).Key findingsWe genotyped 8 STAT4 SNPs (rs11889341, rs7574865, rs8179673, rs6752770, rs925847, rs10168266, rs10181656, and rs11685878) in the STAT4 gene in patients and controls. SNP rs925847 in the STAT4 gene was significantly associated with susceptibility to UC (P = 0.025; OR = 0.63) in dominant genotype analysis, though none of these SNPs were associated with CD susceptibility. Moreover, a significant association was identified between SNP rs11889341 and joint involvement (P = 0.040; OR = 3.79), and between SNP rs925847 and eye involvement (P = 0.030; OR = 2.42) in UC patients. For CD, rs925847 genetic variant was associated with joint (P = 0.029; OR = 3.93) and perianal lesions (P = 0.033; OR = 2.27).SignificanceOur data demonstrated that the STAT4 genetic variants could predispose an individual to IBD and its extra-intestinal ailments in Koreans, suggesting the common pathogenesis of IBD (especially, extra-intestinal manifestations) and other autoimmune diseases.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Life Sciences - Volume 86, Issues 17–18, 24 April 2010, Pages 661–667
نویسندگان
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